The October 22, 2021 Edition of Smackdown Live was a Professional wrestling television show of the WWE's Smackdown brand which took place on October 22, 2021 at the Intrust Bank Arena in Wichita, Kansas. This was the episode after Crown Jewel 2021.
- Numbers in parentheses indicate the length of the match.
- (c) refers to the champion(s) heading into the match.
- Drew McIntyre defeated Sami Zayn (6:50)
- Mansoor defeated Mustafa Ali (2:35)
- Hit Row (Isaiah Scott & Top Dolla) (w/ Ashante Adonis & B-FAB) defeated Dustin Lawyer & Daniel Williams (1:20)
- Happy Corbin (w/ Madcap Moss) defeated King Nakamura (w/ Rick Boogs) (9:20)
Other on-screen talent
- WWE Smackdown Live #1157 at CAGEMATCH.net
- WWE Smackdown Live #1157 at WWE.com
- Smackdown #1157 on WWE Network