The October 12, 2019 episode of Ring of Honor Wrestling was the 421st episode of the show. This episode was recorded on September 28, 2019 at the Sam's Town Hotel & Gambling Hall in Las Vegas, Nevada.
- Numbers in parentheses indicate the length of the match.
- (c) refers to the champion(s) heading into the match.
- Josh Woods & Silas Young defeated Coast 2 Coast (LSG & Shaheem Ali) (9:05)
- Jay Lethal defeated PJ Black in a ROH World Championship #1 Contendership Tournament First Round Match (15:45)