The October 1, 2010 Edition of Smackdown is a Professional wrestling television show of the WWE's Smackdown brand, which took place on October 1, 2010 at the Ford Center in Oklahoma City, Oklahoma. This episode also as the Live SmackDown premiere on Syfy.
- Numbers in parentheses indicate the length of the match.
- (c) refers to the champion(s) heading into the match.
- Dark Match: Kofi Kingston defeated Tyler Reks
- Dolph Ziggler (w/ Vickie Guerrero) (c) vs. Montel Vontavious Porter Ended in a No Contest for the Intercontinental Title (1:40)
- Kelly Kelly, Natalya & The Bella Twins (Brie Bella & Nikki Bella) defeated LayCool (Layla & Michelle McCool), Alicia Fox & Maryse (3:00)
- The Nexus (David Otunga, Heath Slater, Justin Gabriel, Michael Tarver & Wade Barrett) defeated The Big Show by the by referee's decision in a Five On One Handicap Match (2:00)
- The Undertaker (w/ Paul Bearer) defeated CM Punk (5:00)
- Randy Orton defeated Cody Rhodes (w/ Drew McIntyre) (2:40)
- John Cena vs. Kane Ended in a No Contest in a Lumberjack match (8:30)
- Dark Match: Kane (c) vs. The Undertaker Ended in a Double Countout for the World Heavyweight Title
- Dark Match: Randy Orton (c) defeated Sheamus to retain the WWE Championship
- WWE Smackdown #580 at CAGEMATCH.net
- [Smackdown #580 on WWE Network]