The following champion history features the Mexican National Middleweight Championship.
Championship history[]
[...]: Title lineage unclear
| Wrestler: | Times: | Date: | Location: | Notes: |
|---|---|---|---|---|
| Yaqui Joe | 1 | 1933 | ||
| [...] | ||||
| Octavio Gaona | 1 | February 6, 1938 | Mexico City, Mexico | Defeats Black Guzmán. |
| Firpo Segra | 1 | September 2, 1938 | Mexico City, Mexico | |
| Octavio Gaona | 2 | |||
| Tarzán López | 1 | February 9, 1939 | Mexico City, Mexico | |
| Lopez vacates the title on December 16, 1941 to focus on regaining the NWA World Middleweight Championship | ||||
| Murciélago Velázquez | 1 | May 24, 1942 | Mexico City, Mexico | Defeats Octavio Gaona in a tournament final. |
| El Santo | 1 | March 19, 1943 | Mexico City, Mexico | |
| Bobby Bonales | 1 | June 1, 1943 | Mexico City, Mexico | |
| El Santo | 2 | October 8, 1943 | Mexico City, Mexico | |
| Tarzán López | 2 | April 1, 1944 | Mexico City, Mexico | |
| Lopez vacates the title on April 8, 1944 as he already holds the NWA World Middleweight Championship | ||||
| El Santo | 3 | May 31, 1944 | Mexico City, Mexico | Defeats Tuffy Truesdale in a tournament final. |
| Bobby Bonales | 2 | June 1, 1945 | Mexico City, Mexico | |
| Gory Guerrero | 1 | September 25, 1945 | ||
| Guerrero vacates the title on May 28, 1949 when he wins the NWA World Middleweight Championship | ||||
| El Santo | 4 | May 31, 1956 | Mexico City, Mexico | Defeats El Gladiator in a tournament final |
| Karloff Lagarde | 1 | March 24, 1961 | Pachuca de Soto, Hidalgo | |
| El Santo | 5 | June 28, 1963 | Mexico City, Mexico | |
| René Guajardo | 1 | June 22, 1967 | Mexico City, Mexico | |
| Guajardo vacates the title when he wins the NWA World Middleweight Championship | ||||
| Karloff Lagarde | 2 | December 14, 1967 | Pachuca de Soto, Hidalgo | Defeats Apolo Curiel in a tournament final |
| Humberto Garza | 1 | February 25, 1968 | Monterrey, Nuevo León | |
| Alberto Muñoz | 1 | March 9, 1968 | Guadalajara, Guadalajara | |
| René Guajardo | 2 | November 20, 1969 | Guadalajara, Guadalajara | |
| Ciclón Veloz Jr. | 1 | April 6, 1971 | Guadalajara, Guadalajara | |
| Adorable Rubí | 1 | December 14, 1973 | Mexico City, Mexico | |
| Aníbal | 1 | June 28, 1974 | Mexico City, Mexico | |
| Aníbal vacates the title when he wins the NWA World Middleweight Championship | ||||
| Ringo Mendoza | 1 | November 29, 1974 | Mexico City, Mexico | Defeats Aníbal in a tournament final |
| Perro Aguayo | 1 | February 28, 1977 | Mexico City, Mexico | |
| Aguayo vacates the title when he wins the NWA World Middleweight Championship | ||||
| Jose Luis Mendieta | 1 | April 15, 1977 | Mexico City, Mexico | Defeats Adorable Rubí in a tournament final |
| Sangre Chicana | 1 | November 19, 1977 | Mexico City, Mexico | |
| Sangre Chicana vacates the title | ||||
| Cachorro Mendoza | 1 | June 8, 1979 | Mexico City, Mexico | Defeated Sangre Chicana to win the vacant title |
| El Satánico | 1 | October 19, 1979 | Mexico City, Mexico | |
| Satánico vacates the title when he wins the NWA World Middleweight Championship | ||||
| Ringo Mendoza | 2 | June 6, 1980 | Mexico City, Mexico | Defeats El Satanico in a tournament final |
| El Faraón | 1 | December 5, 1980 | Mexico City, Mexico | |
| Faraón vacates the title | ||||
| El Solar | 1 | May 29, 1981 | Mexico City, Mexico | Defeats Cachorro Mendoza in a tournament final |
| El Satánico | 2 | October 23, 1981 | Mexico City, Mexico | |
| Lizmark | 1 | February 19, 1982 | Acapulco de Juárez | |
| Espectro Jr. II | 1 | March 3, 1983 | Cuernavaca, Morelos | |
| Lizmark | 2 | May 28, 1983 | Puebla, Puebla | |
| Lizmark vacates the title when he wins the NWA World Middleweight Championship | ||||
| Ultraman | 1 | August 12, 1983 | Mexico City, Mexico | Defeats Águila Solitaria in a tournament final. |
| Jerry Estrada | 1 | March 4, 1984 | Mexico City, Mexico | |
| Atlantis | 1 | November 30, 1984 | Mexico City, Mexico | |
| Talismán | 1 | March 2, 1986 | Mexico City, Mexico | |
| Mogur | 1 | November 30, 1986 | Mexico City, Mexico | |
| El Satánico | 2 | January 31, 1988 | Mexico City, Mexico | |
| El Dandy | 1 | September 28, 1988 | ||
| Javier Cruz | 1 | July 26, 1990 | Cuernavaca, Morelos | |
| Emilio Charles, Jr. | 1 | August 30, 1990 | Cuernavaca, Morelos | |
| Octagón | 1 | November 20, 1990 | Mexico City, Mexico | |
| Blue Panther | 1 | July 24, 1992 | León, Guanajuato | |
| Octagón | 2 | April 30, 1994 | Veracruz, Veracruz | |
| Blue Panther | 2 | May 27, 1994 | Tijuana, Baja California | Awarded the title by default. Octagón was unable to defend due to injury. |
| El Hijo Del Santo | 1 | January 26, 1996 | Tijuana, Baja California | |
| Fuerza Guerrera | 1 | September 15, 1996 | Saltillo, Coahuila | |
| Octagón | 3 | January 29, 1997 | Naucalpan, México | |
| Pentagón II | 1 | March 28, 1997 | Nezahualcóyotl, México | |
| Abismo Negro | 1 | May 19, 1998 | Tlalnepantla de Baz, México | |
| Espectro Jr. II | 2 | January 27, 1999 | Ecatepec de Morelos, México | |
| Máscara Sagrada, Jr. | 1 | June 17, 1999 | Toluca, México | |
| Espectro Jr. II | 3 | July 8, 1999 | Toluca, México | |
| Pimpinela Escarlata | 1 | April 27, 2001 | Querétaro, Querétaro | |
| Psicosis II | 1 | August 13, 2002 | Huamantla, Tlaxcala | |
| Psicosis was stripped of the title for defending it in an unsanctioned Hardcore match | ||||
| Zumbido | 1 | January 29, 2006 | Salamanca, Guanajuato | Defeats Histeria II in a tournament final. |
| Octagón | 4 | July 15, 2006 | Torreón, Coahuila | |
| Championship vacated | ||||
| Templario | 1 | September 24, 2021 | Mexico City, Mexico | Defeated Dragon Rojo Jr. in a tournament final. |
| Championship vacated when Templario wins the CMLL World Middleweight Championship | ||||
| Guerrero Maya Jr. | 1 | June 2, 2023 | Mexico City, Mexico | Defeated Rugido in a tournament final. |