The May 22, 2003 Edition of Smackdown is a Professional wrestling television show of the WWE's Smackdown brand, which took place on May 20, 2003 at the Greensboro Coliseum in Greensboro, North Carolina.
- Numbers in parentheses indicate the length of the match.
- (c) refers to the champion(s) heading into the match.
- WWE Tag Team Title Match: Eddie Guerrero & Tajiri (c) defeated Team Angle (Charlie Haas & Shelton Benjamin) by DQ (15:32)
- Non-Title Match: Chris Benoit defeated Matt Hardy Version 1.0 (w / Crash & Shannon Moore) (8:06)
- Hardy was the WWE Cruiserweight Champion at the time of this match.
- Non-Title Match: Brock Lesnar defeated Johnny Stamboli by DQ (w / Chuck Palumbo & Nunzio) (4:15)
- Lesnar was the WWE Champion at the time of this match.
- Lie Detector Test Vs. Piper's Job Match: Sean O'Haire (w / Roddy Piper) defeated Mr. America (w / Zach Gowen) (7:00) by Count Out
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