The 22. Aniversario de Arena México (Spanish for "Arena México 22nd Anniversary") show was a major professional wrestling show produced by Empresa Mexicana de Lucha Libre (EMLL) to commemorate the opening of Arena México, the promotion's main venue, in 1956. The event took place on April 21, 1978 as part of a special Friday Night Super Viernes series of shows.
- (c) refers to the champion(s) heading into the match.
- Enrique Vera and Tony Salazar vs. Los Gemelos Diablo (Gemelo Diablo I and Gemelo Diablo II) ended in a draw in a Best two-out-of-three falls tag team match
- Blue Demon and Mano Negra defeated Fishman and Perro Aguayo by disqualification in a Best two-out-of-three falls tag team match
- Harley Race (c) defeated Super Halcón in a Best two-out-of-three falls match to retain the NWA World Heavyweight Championship
- El Faraón and Ringo Mendoza defeated Alfonso Dantés and Sangre Chicana in a Best two-out-of-three falls Lucha de Apuestas Hair vs. Hair match